Clinical Outcome And Prognosis Of Childhood Epilepsy 1996 2006
The goal of this study was to clarify the clinical characteristics and prognostic factors of childhood postencephalitic epilepsy. forty-four patients (20 boys and 24 girls; age range 21 months to 17 years, mean age 8.1 +/- 4.6 years) with postencephalitic epilepsy were selected from the 798 epileptic children treated and followed up at our hospital between 1993 and 2003. Childhood epilepsy: a clinical update. Clinical Outcome And prognosis of childhood epilepsy (1996-2006) the authors described a case of focal epilepsy of childhood with structural brain The goal of this study was to clarify the clinical characteristics and prognostic factors of childhood postencephalitic epilepsy. forty-four patients (20 boys and 24 girls; age range 21 months to 17 years, mean age 8.1 ± 4.6 years) with postencephalitic epilepsy were selected from the 798 epileptic children treated and followed up at our hospital between 1993 and 2003.
P64 – 1656 clinical course and outcome of idiopathic childhood epilepsy: determinants of early and long-term prognosis article (pdf available) in bmc neurology 13(1):206 · december 2013 with 10·5 million children worldwide are estimated to have active epilepsy. over the past 15 years, syndrome-oriented clinical and eeg diagnosis, and better aetiological diagnosis, especially supported by neuroimaging, has helped to clarify the diversity of epilepsy in children, and has improved management. perinatal and postinfective encephalopathy, cortical dysplasia, and hippocampal sclerosis Idiopathic epilepsies and epileptic syndromes predominate childhood and adolescence epilepsy. the aim of the present study was to investigate the clinical course and outcome of idiopathic childhood epilepsy and identify variables determining both early and long-term prognosis. we followed 303 children with newly diagnosed idiopathic epilepsy aged 1–14 years old, both prospectively and Epilepsy is a common neurological disorder characterised by recurring epileptic seizures; it is not a single diagnosis but is a symptom with many underlying causes, more accurately termed the epilepsies. antiepileptic drugs (aeds) to prevent recurrence of seizures form the mainstay of treatment. diagnosis can be challenging, making accurate prevalence estimates difficult. with a prevalence of
Camfield P, Camfield C. Epileptic syndromes in childhood: clinical features, outcomes and treatment. Epilepsia. 2002; 13 (Suppl.3):27–32. [Google Scholar] Shinnar S, Pellock JM. Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol. 2002; 13 (Suppl.1):S4–S17. [Google Scholar] ILAE. Background: In a seven-center prospective observational study of resective epilepsy surgery, the authors examined probability and predictors of entering 2-year remission and the risk of subsequent relapse. Methods: Patients aged 12 years and over were enrolled at time of referral for epilepsy surgery, and underwent standardized evaluation, treatment, and follow-up procedures. Information about the diagnosis and treatment of childhood epilepsy and how epilepsy may affect a child’s life. In the UK, epilepsy affects around 1 in every 200 children and young people under 18. Epilepsy can start at any age including childhood. Cost: 81 € (15% discount for ILAE members with code EPILEPSY) Type: hardcover. The aim of this book is to take a critical look at what is known about outcome of childhood epilepsies, specifically evidencebased findings, and further clarify the direction of clinical and fundamental research for the future. Seizures in children with developmental disabilities Remission Prognosis of epilepsy is influenced strongly by many factors. Most individuals who develop epilepsy have a high likelihood of achieving remission. Eventually, many patients successfully discontinue the use of medications.56–60 Frequency of seizures, type of seizure, and number of seizure types are important predictors of outcome.
The aim of this study was to evaluate the clinical features and prognosis of epileptic seizures associated with TS. The medical records of 29 patients who satisfied the diagnostic criteria for TS and were followed up for at least 2 years at the Department of Pediatrics, Chonnam National University Hospital (CNUH), between January 2000 and Objective: Little is known about the very long-term cognitive outcome in patients with childhood-onset epilepsy. The aim of this unique prospective population-based cohort study was to examine cognitive outcomes in aging participants with childhood-onset epilepsy (mean onset age = 5.3 years) five decades later (mean age at follow-up = 56.5 years). In children, cognitive problems are more diffuse, responsible for language troubles, learning difficulties, poor academic outcome, behavior problems and finally unfortunate socio-professional prognosis. The most devastating epilepsy syndromes such as epileptic encephalopathies are nearly exclusively described in infancy and childhood. Most studies of the prognosis of epilepsy focus on short-term remission of seizures in patients with newly diagnosed epilepsy. 1-5 Outcomes after long-term remission of seizures have been reported Patients experiencing multiple seizure types also appear to have worse outcomes in adults17, 18, 19 and children.20, 21, 22 However, another large community based study, the UK National General Practice Survey of Epilepsy (NGPSE), found only a modest effect of seizure type on prognosis.23, 24, 25 Recent evidence implicates seizure clusters as About 400,000 children in the U.S. have epilepsy, and most of them are able to control their seizures and lead normal lives. That's not to say that dealing with epilepsy is easy, and it will Metabolic changes and electro-clinical patterns in mesio-temporal lobe epilepsy: a correlative study. Brain 2004 ; 127 (Pt 1): 164 –74. Daumas-Duport C , Scheithauer BW , Chodkiewicz JP , Laws ER , Jr. , Vedrenne C. Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Childhood absence epilepsy starting before the age of 4 years and of good prognosis may be a very rare possibility that needs investigation (Darra et al 1996; Sgro et al 1996; Shahar et al 2007). If diagnosis by age at onset is to be followed, the study population should be correctly defined as “epilepsy with childhood absence seizures Epilepsy is a clinical diagnosis defined by an enduring predisposition to generate epileptic seizures. 8 To diagnose epilepsy, epileptic seizures must be differentiated from provoked seizures and other paroxysmal events. Childhood epilepsy has a large spectrum of clinical manifestations, and many other conditions may resemble epilepsy. That's the finding of a new study by researchers in The Netherlands who evaluated the course and outcome of childhood epilepsy in 413 children over a 15-year period. The children were ages 1 month to 16 years (mean age at onset was 5.5 years) when they were diagnosed with epilepsy. They were followed for five years and contacted again 10 years Epilepsy—Childhood—Syndromes—Review—Prognosis— Treatment. The annual incidence of epilepsy is lower in the child-hood years (∼45/100,000 population) than in infancy but still higher than in adolescence (1). Many of the epilep-sies beginning in childhood are relatively benign, al-though there are a few major exceptions. Most, but not
J Child Neurol 1996;11:422-424. Baxter P, Griffiths P, Kelly T, et al. Pyridoxine-dependent seizures: demographic, clinical, MRI and psychometric features, and effect of dose on intelligence quotient. Dev Med Child Neurol. 1996;38:998-1006. McLachlan RS, Brown WF. Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy. Devlin AM, Cross JH, Harkness W, et al. Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence. Brain 2003; 126:556. Basheer SN, Connolly MB, Lautzenhiser A, et al. Hemispheric surgery in children with refractory epilepsy: seizure outcome, complications, and adaptive function. (See "Clinical and laboratory diagnosis of seizures in infants and children" and "Seizures and epilepsy in children: Initial treatment and monitoring".) DEFINITIONS Seizure — A seizure represents the clinical expression of abnormal, excessive, synchronous discharges of neurons residing primarily in the cerebral cortex. N2 - Purpose: To evaluate how diagnostic criteria influence remission rates for patients with childhood absence epilepsy (CAE) and to assess clinical and EEG parameters as predictors of outcome. Methods: One hundred nineteen patients were diagnosed with CAE, according to International League Against Epilepsy (ILAE) classification criteria. The guideline covers diagnosing, treating and managing epilepsy and seizures in children, young people and adults in primary and secondary care. It offers best practice advice on managing epilepsy to improve health outcomes so that people with epilepsy can fully participate in daily life. Prognosis in Childhood Epilepsy — Follow-up Study of 148 Cases in Which Therapy Had Been Suspended after Prolonged Anticonvulsant Control Jean Holowach, M.D., Don L. Thirston, M.D.,
Prevalence ~10% of childhood epilepsies. Incidence ~7/100,000 of children with non-febrile seizures Long-term prognosis of typical childhood absence epilepsy: remission or progression to juvenile myoclonic epilepsy. Neurology. 1996; 47(4):912-8 Fifteen percent of the total cohort had progressed to juvenile myoclonic epilepsy (JME). Multiple clinical and EEG factors were examined as predictors of outcome. Factors predicting no remission (p In clinical epidemiology, prognosis refers to the prediction of course and long‐term outcome of a disease. Prognosis reflects the continuing relationship between predictors and outcomes in a defined population with a defined disease condition (Hemingway, 2006).Studying prognosis helps us understand the course and outcome, as well as the public health impact of the condition (Hesdorfter New Information on Prognosis. Recently published results from a 45-year follow-up study of childhood-onset epilepsy in Finland provide clinicians with updated guideposts for prognosis.  Because Epilepsy Res. 2006 Aug. 70 Suppl 1:S68-76. . Zupanc ML. Clinical evaluation and diagnosis of severe epilepsy syndromes of early childhood. J Child Neurol. 2009 Aug. 24(8 Suppl):6S-14S. . Arzimanoglou A, French J, Blume WT, et al. Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. Appropriate diagnosis and management of childhood epilepsy is essential to improve quality of life in these children. Evidence-based clinical practice guidelines, modified to the Indian setting by a panel of experts, are not available. Process: The Indian Academy of Pediatrics organized a consensus meeting on the diagnosis and management of The aim of this study was to investigate the prognosis of childhood epilepsy and to analyze prognostic factors in addition to remission rate in a follow-up of newly referred patients. Two hundred eighty-one patients were followed for a mean period of 5.3 years. Many children with severe epilepsy syndromes have additional difficulties with learning and behaviour and may need extra support. Examples of childhood epilepsy syndromes Benign rolandic epilepsy (BRE) This syndrome affects 15% of children with epilepsy and can start at any time between the ages of 3 and 10. Summary: The educational and social progress of a child with epilepsy depends not only on seizure control but also on cognitive and behavioral factors. The various epilepsy syndromes of childhood and adolescence differ greatly in terms of cognitive and behavioral outcome. A high proportion of babies who have West syndrome and children who have Dravet syndrome (severe myoclonic epilepsy in A benign partial epilepsy of childhood, this condition, benign epilepsy of childhood with centrotemporal spikes (becct), is defined within the international league against epilepsy (ilae) classification scheme as an idiopathic age- and localization-related epileptic syndrome with a combination of clinical and eeg characteristics used for diagnosis.
Epilepsy adversely affects the physical, mental, and social well-being of persons 1,2 and is associated with a 2 to 3 times greater mortality rate compared with the general population. 3,4 practice guidelines recommend prompt treatment with an antiepileptic drug (aed) following a confirmed diagnosis of epilepsy. 5 untreated persons with epilepsy may experience higher complication rates such as Introduction. studies of the natural history of new-onset childhood epilepsy indicate that seizures can be controlled in up to two out of three patients (sillanpää and schmidt, 2006).however, seizure outcome varies considerably in the epilepsies, even between patients with seemingly the same epilepsy syndrome, and its determinants are largely unknown (schmidt and löscher, 2005). Panayiotopoulos syndrome (named after c. p. panayiotopoulos) is a common idiopathic childhood-related seizure disorder that occurs exclusively in otherwise normal children (idiopathic epilepsy) and manifests mainly with autonomic epileptic seizures and autonomic status epilepticus. an expert consensus has defined panayiotopoulos syndrome as "a benign age-related focal seizure disorder Elaine c. wirrell, m.d., is the director of pediatric epilepsy at mayo clinic. her clinical focus includes: early-onset epilepsies and epileptic encephalopathies, including west syndrome, dravet syndrome, myoclonic atonic epilepsy of doose, lennox-gastaut syndrome and csws It is of great clinical value to be able to reassure patients that the diagnosis of incident drug-resistant epilepsy does not carry an ominous prognosis that has been well described for those with